Abstract—With the release of a series of State Council documents such as "Made in China 2025" and "Healthy China Action (2019–2030)", the integration of medical and engineering interdisciplinary fields has become one of the key construction areas of higher education in China. In response to the problem of low coupling between interdisciplinary majors in the current integration of medicine and engineering, and the inability to provide effective support for each other, this article takes the interdisciplinary knowledge crossing course "Medical Data Mining" as an example. Through the teaching mode of integrating science and education, the design concept of medical data mining course is reconstructed, the teaching content is reconstructed, the theoretical knowledge application is increased, the practical skills and scientific literacy of students are improved, and ideological and political education and interdisciplinary vocational literacy education are integrated. Students are guided to regard disease prevention, pain relief, and safeguarding the health rights and interests of the masses as the sacred responsibility of medical workers. A bridge between education, industry, and innovation is built to achieve seamless integration of talent cultivation, industrial development, and technological innovation, and to improve the training mode of scientific and technological innovation talents in the integration of medicine and engineering interdisciplinary fields.